[环孢素A对小鼠胰岛细胞的作用]
[The effect of cyclosporin A on the islet cells of mice].
作者信息
Gol'dberg E D, Eshchenko V A, Bovt V D, Tolok A Ia
出版信息
Biull Eksp Biol Med. 1992 Nov;114(11):491-2.
PMID:1290820
Abstract
The action of immunosuppressive agent ciclosporin A on the insular apparatus was studied with an original method of cytochemical zinc detection in experiments on mice. The drug was found to lower zinc levels in pancreatic beta-cells. In ciclosporin A pretreatment the sensitivity of mice to zinc-binding diabetogenic agent enhanced.
摘要
采用一种在小鼠实验中进行细胞化学锌检测的原创方法，研究了免疫抑制剂环孢素A对胰岛装置的作用。发现该药物可降低胰腺β细胞中的锌水平。在环孢素A预处理后，小鼠对锌结合致糖尿病剂的敏感性增强。
Zotero 插件