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[环孢素A对小鼠胰岛细胞的作用]

[The effect of cyclosporin A on the islet cells of mice].

作者信息

Gol'dberg E D, Eshchenko V A, Bovt V D, Tolok A Ia

出版信息

Biull Eksp Biol Med. 1992 Nov;114(11):491-2.

PMID:1290820
Abstract

The action of immunosuppressive agent ciclosporin A on the insular apparatus was studied with an original method of cytochemical zinc detection in experiments on mice. The drug was found to lower zinc levels in pancreatic beta-cells. In ciclosporin A pretreatment the sensitivity of mice to zinc-binding diabetogenic agent enhanced.

摘要

采用一种在小鼠实验中进行细胞化学锌检测的原创方法，研究了免疫抑制剂环孢素A对胰岛装置的作用。发现该药物可降低胰腺β细胞中的锌水平。在环孢素A预处理后，小鼠对锌结合致糖尿病剂的敏感性增强。

相似文献

1
[The effect of cyclosporin A on the islet cells of mice].[环孢素A对小鼠胰岛细胞的作用]
Biull Eksp Biol Med. 1992 Nov;114(11):491-2.
2
[The effect of diabetogenic substances on the zinc and calcium content in the pancreatic islet cells of rabbits].[致糖尿病物质对家兔胰岛细胞中锌和钙含量的影响]
Biull Eksp Biol Med. 1991 Feb;111(2):135-7.
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[The dynamics of the Zn content in the pancreatic islets of rabbits after the administration of the diabetogenic agent dithizone].[给予致糖尿病剂双硫腙后家兔胰岛中锌含量的动态变化]
Patol Fiziol Eksp Ter. 1991 Jul-Aug(4):43-5.
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Primary insulin insufficiency after blocking of zinc in pancreatic beta-cells.胰腺β细胞中锌被阻断后原发性胰岛素分泌不足。
Endocrinol Exp. 1981;15(2):99-109.
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[The effect of physiological and extreme irritants on zinc metabolism in pancreatic islets and hippocampus cells].[生理刺激物和极端刺激物对胰岛及海马体细胞锌代谢的影响]
Fiziol Zh (1994). 2001;47(2):66-9.
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[Effect of fasting, glucose load and dithizone injections on the zinc content in pancreatic islets of the rabbit].[禁食、葡萄糖负荷及双硫腙注射对兔胰岛锌含量的影响]
Patol Fiziol Eksp Ter. 1990 Nov-Dec(6):38-9.
7
[Zinc contents of pancreatic islets in animals of various species after administration of diabetogenic agent, dithizone].[给予致糖尿病药物双硫腙后不同物种动物胰岛的锌含量]
Biull Eksp Biol Med. 1992 Jan;113(1):53-5.
8
Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia.糖尿病（db/db）突变型C57BL/KsJ小鼠功能性胰岛细胞结构的雌激素恢复：与雌二醇定位、全身血糖和持续性高胰岛素血症的关系。
Cell Tissue Res. 2005 Feb;319(2):231-42. doi: 10.1007/s00441-004-1019-y. Epub 2004 Nov 20.
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[State of the islands of Langerhans in various animal species after administration of 8-(arensulfonylamino)-quinolines].[给予8-（芳磺酰氨基）喹啉后不同动物物种胰岛的状态]
Probl Endokrinol (Mosk). 1978 May-Jun;24(3):103-7.
10
[T effect of pararenal novocaine blockade on the zinc content of the pancreas, the histophysiology of its insular apparatus and the sensitivity of white rats to insulin].
Biull Eksp Biol Med. 1969 Mar;67(3):60-3.