Eshchenko V A
Probl Endokrinol (Mosk). 1978 May-Jun;24(3):103-7.
The action of 8-(arensulfonylamino)-quinolines on the insular tissue of the pancreas was studied in frogs, pigeons, mice, golden hamsters, rats, rabbits, cats and dogs. There eas a decrease of zinc content in the Langerhans islets at the earliest stages after injection of the drug. Other histochemical components and histostrucutre of the islets changed with the more pronounced effect of the drug. Permanent diabetes with characteristic morphological picture of the pancreas developed in rabbits only. A possible action of chelating factors on human Langerhans islets is suggested on the basis of comparative pathological study.
研究了8-（芳磺酰氨基）喹啉对青蛙、鸽子、小鼠、金黄仓鼠、大鼠、兔子、猫和狗的胰腺胰岛组织的作用。注射该药物后最早阶段，朗格汉斯胰岛中的锌含量就有所下降。胰岛的其他组织化学成分和组织结构随着药物作用的增强而发生变化。仅在兔子身上出现了伴有胰腺特征性形态学表现的永久性糖尿病。基于比较病理学研究，提示了螯合因子对人朗格汉斯胰岛可能的作用。
