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[异相睡眠剥夺期间某些脑结构中神经元的超微结构重组]

[The ultrastructural reorganization of the neurons in some brain formations during the deprivation of paradoxical sleep].

作者信息

Abushov B M, Bogolepov N N, Melikhov E M

出版信息

Biull Eksp Biol Med. 1992 Nov;114(11):534-6.

PMID:1290836
Abstract

Electron microscopy was used to study intracellular changes in the dorsal hippocampus, lateral hypothalamic nucleus and pontine reticular formation of rats after 96-hour paradoxical sleep deprivation. It was found that compensative-accommodative processes predominate in the majority of neurons. At the same time destructive changes are detected in some cells. In changed neurons the ultrastructural signs of damage to protein-synthesizing apparatus were observed. These changes can be as a result of disturbances of protein biosynthesis.

摘要

采用电子显微镜研究了大鼠在96小时异相睡眠剥夺后背侧海马、外侧下丘脑核和脑桥网状结构中的细胞内变化。结果发现,大多数神经元中以代偿性适应过程为主。与此同时,在一些细胞中检测到了破坏性变化。在发生变化的神经元中,观察到了蛋白质合成装置受损的超微结构迹象。这些变化可能是蛋白质生物合成紊乱的结果。

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