Swartz Marvin S, Perkins Diana O, Stroup T Scott, McEvoy Joseph P, Nieri Jennifer M, Haak David C
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3173, Durham, NC 27710, USA.
Schizophr Bull. 2003;29(1):33-43. doi: 10.1093/oxfordjournals.schbul.a006989.
Schizophrenia is a symptomatically heterogeneous disorder characterized by the presence of positive and negative symptoms, and variable impairment in community functioning. Given the diversity of symptom presentations and functioning associated with schizophrenia, one of the key challenges facing the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial was the selection of efficient assessment measures appropriate to a community-based effectiveness trial. This article describes the rationale for the measurement approach adopted for the trial, provides a brief overview of the selected measures, and describes the process of training assessment raters for a large and geographically dispersed study group.
精神分裂症是一种症状表现异质性的疾病，其特征为存在阳性和阴性症状，以及社区功能的不同程度损害。鉴于与精神分裂症相关的症状表现和功能的多样性，临床抗精神病药物干预有效性试验（CATIE）精神分裂症试验面临的关键挑战之一是选择适合基于社区的有效性试验的有效评估措施。本文描述了该试验所采用测量方法的基本原理，简要概述了所选措施，并描述了为一个规模大且地域分散的研究组培训评估评分员的过程。
