Charles Stewart Mott Department of Public Health, College of Human Medicine, Michigan State University, 200 East 1st Street, Flint, MI 48502, USA.
Department of Psychological Science, School of Social Ecology, University of California at Irvine, Irvine, CA 92697-1075, USA; Institute for Interdisciplinary Salivary Bioscience Research, University of California at Irvine, 4201 SBSG, Irvine, CA 92697-7085, USA; John Hopkins University School of Medicine, 615 North Wolfe St., Baltimore, MD 21205, USA.
Psychoneuroendocrinology. 2024 Oct;168:107120. doi: 10.1016/j.psyneuen.2024.107120. Epub 2024 Jul 2.
Acute physiological responses to psychosocial stressors are a potential pathway underlying racial disparities in stress-related illnesses. Uric acid (UA) is a potent antioxidant that has been linked to disparities in stress-related illnesses, and recent research has shown that UA is responsive to acute social stress. However, an examination of the relationships between the purinergic system and other commonly measured stress systems is lacking. Here, we measure and characterize associations of salivary uric acid (sUA) with markers of hypothalamic-pituitary-adrenal (HPA) axis activation, sympathetic-adreno-medullar (SAM) axis activation, and acute inflammation. A community sample of 103 African Americans (33 male, 70 female) completed the Trier Social Stress Test to induce social-evaluative threat. Passive drool collected before, during, and after the stressor task provided salivary reactivity measures of UA (sUA), cortisol, dehydroepiandrosterone sulfate (DHEAS), salivary alpha amylase (sAA - a surrogate marker of SAM activity) and C-reactive protein (sCRP). Multiple regressions revealed that total activation of cortisol, DHEAS, and sCRP were each positively associated with higher total activation of sUA. Additionally, DHEAS reactivity was positively associated with sUA reactivity. Relationships between HPA-axis markers and sUA were especially observed among younger and male participants. Overall, findings suggest potential coordination of stress systems with sUA in response to acute stress, which may further the contributions of biological stress processes to racial health disparities.
急性生理应激反应是导致与压力相关疾病的种族差异的潜在途径。尿酸（UA）是一种有效的抗氧化剂，与压力相关疾病的差异有关，最近的研究表明 UA 对急性社会应激有反应。然而，嘌呤能系统与其他常见的应激系统之间的关系尚未得到检验。在这里，我们测量并描述唾液尿酸（sUA）与下丘脑-垂体-肾上腺（HPA）轴激活、交感神经-肾上腺髓质（SAM）轴激活和急性炎症标志物之间的关系。一个由 103 名非裔美国人（33 名男性，70 名女性）组成的社区样本完成了特里尔社会应激测试，以诱发社会评价威胁。在应激任务之前、期间和之后收集的被动流涎提供了 UA（sUA）、皮质醇、脱氢表雄酮硫酸盐（DHEAS）、唾液α-淀粉酶（sAA- SAM 活性的替代标志物）和 C 反应蛋白（sCRP）的唾液反应性测量值。多元回归显示，皮质醇、DHEAS 和 sCRP 的总激活与 sUA 的总激活呈正相关。此外，DHEAS 的反应性与 sUA 的反应性呈正相关。在年轻和男性参与者中观察到 HPA 轴标志物与 sUA 之间的关系尤为明显。总的来说，这些发现表明应激系统与 sUA 之间存在潜在的协调作用，以应对急性应激，这可能会进一步促进生物应激过程对种族健康差异的贡献。
