Claude Valère, Couture Christian, Battin-Bertho Régine, Grossin Maggy, Lagace Réal, Hénin Dominique
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Bichat, 75018 Paris, France.
Ann Pathol. 2003 Jun;23(3):258-60.
Nora's lesion, also known as bizarre parosteal osteochondromatous proliferation (B.P.O.P.), involves mostly the small tubular bones of the hands and feet. Histologically, it is characterized by a proliferation of chondroid, bony and fibrous tissues, sometimes with high cellular density, bizarre chondrocytes but is devoid of cellular atypia and necrosis. Distinct blue color is noted at the interface of bone and cartilage. The most important lesions that present differential diagnostic problems are chondrosarcoma, parosteal osteosarcoma and florid reactive periostitis. The lesion is benign but may recur locally in as many as 55%. The clinical and pathological findings of four cases of Nora's lesion are presented.
诺拉氏病变，也称为奇异骨旁骨软骨瘤性增殖（B.P.O.P.），主要累及手足的小管状骨。组织学上，其特征为软骨样、骨样和纤维组织的增殖，有时细胞密度较高，有奇异的软骨细胞，但无细胞异型性和坏死。在骨与软骨的界面处可见明显的蓝色。呈现鉴别诊断问题的最重要病变是软骨肉瘤、骨旁骨肉瘤和 florid 反应性骨膜炎。该病变为良性，但局部复发率可能高达55%。本文介绍了4例诺拉氏病变的临床和病理表现。
