自然流产中绒毛膜组织促炎细胞因子的分泌

Secretion of proinflammatory cytokines by villous chorion tissue in spontaneous abortion.

作者信息

Pavlov O V, Sel'kov S A, Lalayan D V, Arzhanova O N

机构信息

Laboratory of Immunology, D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg.

出版信息

Bull Exp Biol Med. 2003 Apr;135(4):377-9. doi: 10.1023/a:1024621100429.

DOI:10.1023/a:1024621100429

PMID:12910313

Abstract

Secretion of proinflammatory cytokines IL-1 beta, TNF-alpha, IL-6, IFN-alpha, and IFN-gamma by the chorion tissue (8-12 weeks) was studied in normal gestation and spontaneous abortion. The production of IL-1 beta, TNF-alpha, and IFN-alpha virtually did not change in spontaneous abortion, while IFN-gamma was not secreted in all experimental groups. The production of IL-6 increased more than 2-fold in patients with spontaneous abortion during the first trimester. These data confirm the involvement of this cytokine in the reproductive processes and in the pathogenesis of miscarriage.

摘要

在正常妊娠和自然流产中，研究了绒毛组织（8 - 12周）促炎细胞因子白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、干扰素-α（IFN-α）和干扰素-γ（IFN-γ）的分泌情况。在自然流产中，IL-1β、TNF-α和IFN-α的产生实际上没有变化，而在所有实验组中均未分泌IFN-γ。在孕早期自然流产患者中，IL-6的产生增加了2倍多。这些数据证实了这种细胞因子参与生殖过程以及流产的发病机制。