Prochazka Helena, Agren Hans
Göteborg University Institute of Clinical Neuroscience, Department of Psychiatry, Sahlgrenska University Hospital/Mölndal, 43180 Mölndal, Sweden.
Eur Arch Psychiatry Clin Neurosci. 2003 Aug;253(4):185-92. doi: 10.1007/s00406-003-0423-8.
Outward-directed violence and impulsivity in humans and primates has frequently been related to abnormal brain monoaminergic turnover. Self-rated aggression is likely to be clinically relevant,and its psychobiological basis needs investigation.
Sixty-six patients (40 women and 26 men) with persistent depressive disorder (PDD) were compared with 497 control subjects from the general Swedish population.
We administered the Aggression Questionnaire - Revised Swedish Version (AQ-RSV) to patients and control subjects. In patients, CSF 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-5-hydroxyphenylglycol (MHPG) in CSF were analyzed. Total Aggression score and Aggression subfactors 'Physical Aggression','Verbal Aggression','Anger', and 'Hostility'were correlated with CSF concentrations of 5-hydroxyindoleacetic acid (5-HIAA),and 3-methoxy-5-hydroxyphenylglycol (MHPG).
Overall, Hostility was positively related to CSF MHPG (t=2.27, p=0.015). Split by sex,Hostility was related with 5-HIAA in males (r=0.62,p=0.003),and with MHPG in females (r=0.38, p=0.03). Comparing self rated aggression with age- and sex-matched data from the general Swedish population, the most prominent deviation was increased Hostility score among PDD patients. Among patients, all aggression factors were nominally higher in women than in men, with the most pronounced sex difference in Hostility (t=-1.89, p=0.04).
Results suggest a clinically meaningful sex difference in a positive relationship between hostility and serotonergic/noradrenergic turnover in PDD patients.
人类和灵长类动物的外向性暴力和冲动行为常常与大脑单胺能代谢异常有关。自评攻击性可能具有临床相关性，其心理生物学基础需要进行研究。
将66例持续性抑郁症（PDD）患者（40名女性和26名男性）与497名来自瑞典普通人群的对照者进行比较。
我们对患者和对照者施测了《攻击性问卷 - 瑞典修订版》（AQ-RSV）。对患者的脑脊液5-羟吲哚乙酸（5-HIAA）和脑脊液3-甲氧基-5-羟苯乙二醇（MHPG）进行分析。总攻击性得分以及攻击性子因素“身体攻击”“言语攻击”“愤怒”和“敌意”与脑脊液5-羟吲哚乙酸（5-HIAA）和3-甲氧基-5-羟苯乙二醇（MHPG）的浓度进行相关性分析。
总体而言，敌意与脑脊液MHPG呈正相关（t = 2.27，p = 0.015）。按性别划分，男性的敌意与5-HIAA相关（r = 0.62，p = 0.003），女性的敌意与MHPG相关（r = 0.38，p = 0.03）。将自评攻击性与来自瑞典普通人群的年龄和性别匹配数据进行比较，最显著的偏差是PDD患者的敌意得分升高。在患者中，所有攻击性因素在女性中名义上均高于男性，敌意方面的性别差异最为明显（t = -1.89，p = 0.04）。
结果表明，PDD患者中敌意与血清素能/去甲肾上腺素能代谢之间的正向关系存在具有临床意义的性别差异。
