Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, 5841, South Maryland Avenue, Chicago, IL 60637, USA.
J Neural Transm (Vienna). 2010 Feb;117(2):241-8. doi: 10.1007/s00702-009-0359-x.
While the relationship between cerebrospinal fluid 5-HIAA (CSF 5-HIAA) and aggression is typically reported as inverse, studies of some groups of aggressive individuals demonstrate a positive (or no) relationship, between these two variables. It is possible that simultaneous examination of both CSF 5-HIAA and CSF homovanillic acid (HVA), which co-vary in human subjects may clarify differences in reported findings in different groups of aggressive individuals. CSF 5-HIAA and CSF HVA concentrations were simultaneously examined in 60 healthy human subjects (40 with personality disorder and 20 healthy controls) and were correlated with measures of aggression and impulsivity. CSF 5-HIAA concentrations correlated positively, and CSF HVA concentrations correlated inversely, with a composite measure of impulsive aggression in all subjects as well as in the personality disordered subjects. The CSF 5-HIAA findings are consistent with those demonstrating reduced post-synaptic 5-HT receptor responsiveness to 5-HT agent challenge and suggest differences in the pathophysiology between different groups of subjects with aggressive behavior, particularly with regard to severity of aggressive behavior.
虽然脑脊液 5-羟吲哚乙酸（CSF 5-HIAA）与攻击行为之间的关系通常呈负相关，但对某些具有攻击性个体群体的研究表明，这两个变量之间存在正相关（或无相关性）。同时检查脑脊液 5-HIAA 和 CSF 高香草酸（HVA），这两种物质在人体中是共同变化的，这可能会澄清不同攻击性个体群体报告的研究结果中的差异。对 60 名健康人类受试者（40 名患有人格障碍，20 名健康对照）同时检查了 CSF 5-HIAA 和 CSF HVA 浓度，并与攻击性和冲动性的测量值进行了相关分析。在所有受试者以及人格障碍受试者中，CSF 5-HIAA 浓度与冲动性攻击的综合测量值呈正相关，而 CSF HVA 浓度则呈负相关。CSF 5-HIAA 的发现与那些证明突触后 5-HT 受体对 5-HT 激动剂挑战的反应性降低的发现一致，这表明具有攻击行为的不同个体群体之间的病理生理学存在差异，特别是在攻击行为的严重程度方面。
