De Bellis M D, Geracioti T D, Altemus M, Kling M A
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland.
Biol Psychiatry. 1993;33(8-9):636-41. doi: 10.1016/0006-3223(93)90103-k.
Cerebrospinal fluid (CSF) levels of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and homovanillic acid (HVA) were measured in three groups: 46 healthy volunteers; 9 medication-free patients with DSM III-R major depressive disorder, recurrent; and these same 9 patients following at least 4 weeks of fluoxetine treatment at 20 mg/day. CSF monoamine metabolite levels in medication-free patients did not differ from healthy volunteers; however, CSF 5-HIAA and MHPG decreased significantly from 95.9 +/- 24.6 (all values +/- SD) to 64.2 +/- 26.1 pmol/ml and from 46.7 +/- 14.2 to 42.6 +/- 11.6 pmol/ml, respectively, following fluoxetine treatment. Fluoxetine also significantly decreased mean Hamilton Depression Rating Scale scores from 23.2 +/- 6.5 to 17.4 +/- 5.0 and significantly increased the CSF HVA/5-HIAA ratio.
对三组人群的脑脊液（CSF）中5-羟吲哚乙酸（5-HIAA）、3-甲氧基-4-羟基苯乙二醇（MHPG）和高香草酸（HVA）这三种单胺代谢产物水平进行了测量：46名健康志愿者；9名未服用药物的复发性DSM III-R重度抑郁症患者；以及这9名患者在接受至少4周、每日20毫克氟西汀治疗之后的情况。未服用药物的患者脑脊液单胺代谢产物水平与健康志愿者并无差异；然而，接受氟西汀治疗后，脑脊液5-HIAA和MHPG水平分别从95.9±24.6（所有数值±标准差）显著降至64.2±26.1皮摩尔/毫升，以及从46.7±14.2降至42.6±11.6皮摩尔/毫升。氟西汀还使汉密尔顿抑郁量表平均得分从23.2±6.5显著降至17.4±5.0，并显著提高了脑脊液HVA/5-HIAA比值。
