辣椒素和薄荷醇在瘙痒和疼痛治疗中的应用：最近克隆出的受体是关键所在。
Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key.
作者信息
Anand P
机构信息
Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, UK.
出版信息
Gut. 2003 Sep;52(9):1233-5. doi: 10.1136/gut.52.9.1233.
Abstract
Topical capsaicin is reported to be an effective treatment for idiopathic intractable pruritus ani. While both capsaicin and menthol application produce a transient perianal burning sensation, only capsaicin relieves itching. Classical observations on functional desensitisation of nociceptors by capsaicin may explain the beneficial effects but the recent discovery of a range of receptors which respond to capsaicin, menthol, and temperature, and their expression in subsets of sensory nerve fibres, provides an exciting prospect towards advancing our understanding and treatment of sensory dysfunction.
摘要
据报道，局部应用辣椒素是治疗特发性顽固性肛门瘙痒症的有效方法。虽然应用辣椒素和薄荷醇都会产生短暂的肛周烧灼感，但只有辣椒素能缓解瘙痒。关于辣椒素对伤害感受器功能脱敏的经典观察结果或许可以解释其有益效果，但最近发现的一系列对辣椒素、薄荷醇和温度有反应的受体，以及它们在感觉神经纤维亚群中的表达，为增进我们对感觉功能障碍的理解和治疗提供了令人兴奋的前景。
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