Miki Atsushi, Liu Grant T, Goldsmith Zachariah G, Liu Chia-Shang J, Haselgrove John C
Functional MRI Research Unit, Children's Hospital of Philadelphia, and Division of Neuro-Ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Ophthalmologica. 2003 Sep-Oct;217(5):365-9. doi: 10.1159/000071353.
Although postmortem morphological changes in the lateral geniculate nucleus (LGN) have been reported in human amblyopia, LGN function during monocular viewing by amblyopic eyes has not been documented in humans. We used functional magnetic resonance imaging (fMRI) to study monocular visual activation of the LGN in a patient with anisometropic amblyopia. Four normal subjects, a patient with optic neuritis and a patient with anisometropic amblyopia were studied with fMRI at 1.5 T during monocular checkerboard stimulation. Activated areas in the LGN and visual cortex were identified after data processing (motion correction and spatial normalization) with SPM99. In the 4 normal subjects, comparable activation of the LGN and visual cortex was obtained by stimulation of either the right or left eye. In the patient with unilateral optic neuritis, activation of the LGN and visual cortex was markedly decreased when the affected eye was stimulated. Similarly, decreased activation of the LGN as well as the visual cortex by the affected eye was demonstrated in the patient with anisometropic amblyopia. Our preliminary results suggest that activation of the LGN is diminished during monocular viewing by affected eyes in anisometropic amblyopia. fMRI appears to be a feasible method to study LGN activity in human amblyopia.
尽管已有报道称人类弱视患者外侧膝状核（LGN）存在死后形态学变化，但人类弱视眼单眼注视期间LGN的功能尚未得到记录。我们使用功能磁共振成像（fMRI）研究了一名屈光参差性弱视患者LGN的单眼视觉激活情况。在单眼棋盘格刺激期间，对4名正常受试者、1名视神经炎患者和1名屈光参差性弱视患者进行了1.5T的fMRI研究。使用SPM99对数据进行处理（运动校正和空间归一化）后，确定了LGN和视觉皮层的激活区域。在4名正常受试者中，刺激右眼或左眼均可获得LGN和视觉皮层的可比激活。在单侧视神经炎患者中，刺激患眼时LGN和视觉皮层的激活明显降低。同样，屈光参差性弱视患者的患眼也表现出LGN以及视觉皮层的激活降低。我们的初步结果表明，屈光参差性弱视患者患眼单眼注视期间LGN的激活减弱。fMRI似乎是研究人类弱视中LGN活动的一种可行方法。
