7-imidazolylalkanamido-1-carboxylalkylbenzo-diazepine, a novel series of farnesyltransferase inhibitors.
作者信息
Wan Sheng-biao, Chu Feng-ming, Guo Zong-ru
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
出版信息
Yao Xue Xue Bao. 2002 Jul;37(7):516-21.
PMID:12914320
Abstract
AIM
Design, synthesis and evaluation of a series of 7-imidazolylalkanamido-1-carboxylalkylbenzodiazepine farnesyltransferase (FTase) inhibitors.
METHODS AND RESULTS
Coupling of imidazolylalkylcarboxylic acids and 1-substituted 7-aminobenzodiazepines (5a-5c) yielded 10 new compounds (6-12, 16-18) which were biologically tested against FTase using scintillation proximity assay method.
CONCLUSION
Five target compounds were found to be potential farnesyltransferase inhibitors.
摘要
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