Vega Matuszczyk Josefa
Department of Behavioral Sciences, University Trollhättan-Uddevalla, Vänersborg, Sweden.
Scand J Psychol. 2003 Jul;44(3):251-6. doi: 10.1111/1467-9450.00342.
An attempt to elucidate the possible role of prenatal estrogen on the development of feminine sexual behavior and reproductive function was made by treating females with the antiestrogen CI628 prenatally on days 13-19. Control females were prenatally treated with saline or remained untreated. The animals were delivered by caesarian section on day 22 of pregnancy and placed with foster mothers whose newborn pups had been previously removed. Intact peripubertal females in each treatment group were observed for several reproductive measures, including the capacity to become pregnant. Other females were ovariectomized in adulthood and treated with estradiol benzoate (EB) (1, 1.5, 2 or 4 micro g/rat) and 0.5 mg progesterone and tested for receptivity, proceptivity and sexual partner preference. Two weeks after the completion of these tests, the females were injected daily for 7 days with 0.25 mg testosterone and tested for sexual partner preference and mounting behavior. The results obtained showed accelerated vaginal opening, and infertility in the antiestrogen-treated intact females and enhanced receptivity and proceptivity in response to 1 micro g EB in the antiestrogen ovariectomized females. Sexual partner preference and mounting behavior did not differ between groups. These results suggest an involvement of prenatal estrogen on the development of female reproductive function, but not on behavioral differentiation.
通过在妊娠第13至19天对雌性动物进行抗雌激素CI628处理，试图阐明产前雌激素在女性性行为和生殖功能发育中的可能作用。对照雌性动物在产前接受生理盐水处理或不接受处理。在妊娠第22天通过剖腹产分娩动物，并将其与事先已移除新生幼崽的代孕母亲放在一起。对每个处理组中完整的青春期前雌性动物进行了多项生殖指标观察，包括受孕能力。其他雌性动物在成年后进行卵巢切除，并用苯甲酸雌二醇（EB）（1、1.5、2或4微克/大鼠）和0.5毫克孕酮进行处理，然后测试其接受性、求偶性和性伴侣偏好。在这些测试完成两周后，每天给雌性动物注射0.25毫克睾酮，持续7天，然后测试其性伴侣偏好和骑跨行为。所得结果显示，抗雌激素处理的完整雌性动物阴道开口加速且不育，而抗雌激素卵巢切除的雌性动物对1微克EB的接受性和求偶性增强。各实验组之间的性伴侣偏好和骑跨行为没有差异。这些结果表明产前雌激素参与了雌性生殖功能的发育，但未参与行为分化。
