Vega Matuszczyk J V, Larsson K
Department of Psychology, University of Göteborg, Sweden.
Horm Behav. 1995 Jun;29(2):191-206. doi: 10.1006/hbeh.1995.1014.
Male rats were prenatally (Day 10-19 of pregnancy) exposed to an antiestrogen, nitromifene citrate (CI628, 1 mg/rat), or an antiandrogen, cyproterone acetate (CA, 10 mg/rat), and in adulthood were examined for their exhibition of male-typical and female-typical behavior pattern. Treatment with CI628 abolished the capacity of the adult intact male to ejaculate, enhanced his potential to exhibit feminine sexual behavior, and decreased the intensity of the level of female-oriented behavior in a two-choice stimulus situation (estrous female vs active male). The administration of testosterone (T) did not alter these behaviors. Males exposed to CA showed low levels of lordosis behavior and normal levels of female-oriented preference. Further, they showed increased frequency of mounts and decreased number of intromissions, and only a few males ever ejaculated. Macroscopic inspection of the genital organs of the CI628-treated males revealed complete absence of the prostate. The dissections of the CA-treated males revealed a poorly developed penis and a blind-ending vagina. It was concluded that prenatal estrogen (E) is involved (1) in determining the development of mechanisms destined to mediate the display of male-typical behaviors in adulthood, (2) in suppressing the development of mechanisms of female-typical behaviors, and (3) seems to stimulate neural mechanisms influencing sexual preference behavior in the adult.
雄性大鼠在孕期（妊娠第10 - 19天）接受抗雌激素药物枸橼酸硝米芬（CI628，1毫克/只大鼠）或抗雄激素药物醋酸环丙孕酮（CA，10毫克/只大鼠）处理，成年后检测其雄性典型和雌性典型行为模式的表现。用CI628处理后，成年未阉割雄性大鼠的射精能力丧失，表现出雌性性行为的可能性增加，并且在双选刺激情境（发情期雌性大鼠与活跃雄性大鼠）中，以雌性为导向的行为水平强度降低。给予睾酮（T）并未改变这些行为。暴露于CA的雄性大鼠表现出低水平的脊柱前凸行为和正常水平的以雌性为导向的偏好。此外，它们的爬跨频率增加，插入次数减少，只有少数雄性大鼠射精。对经CI628处理的雄性大鼠生殖器官进行大体检查发现前列腺完全缺失。对经CA处理的雄性大鼠进行解剖发现阴茎发育不良且阴道盲端。研究得出结论，产前雌激素（E）参与：（1）决定成年期介导雄性典型行为表现的机制的发育；（2）抑制雌性典型行为机制的发育；（3）似乎刺激影响成年期性偏好行为的神经机制。
