生长激素对人体脂质代谢的影响。

Effects of growth hormone on lipid metabolism in humans.

作者信息

Møller Niels, Gjedsted Jakob, Gormsen Lars, Fuglsang Jens, Djurhuus Christian

机构信息

Medical Department M (Endocrinology and Diabetes), Institute of Experimental Research, University of Aarhus, Aarhus C, 8000, Denmark.

出版信息

Growth Horm IGF Res. 2003 Aug;13 Suppl A:S18-21. doi: 10.1016/s1096-6374(03)00048-0.

DOI:10.1016/s1096-6374(03)00048-0

PMID:12914720

Abstract

The most immediate effect of growth hormone (GH) administration in humans is a significant increase in free fatty acids after 1-2 h, reflecting stimulation of lipolysis and ketogenesis. This stimulation represents an important physiological adaptation to stress and fasting. When the capacity of GH to increase lipolysis is blocked, the protein-retaining and insulin-antagonistic effects of GH on glucose metabolism are either abolished or weakened dramatically, compatible with a key role for lipolysis in orchestrating the metabolic actions of GH.

摘要

在人类中，注射生长激素（GH）最直接的作用是在1-2小时后游离脂肪酸显著增加，这反映了脂肪分解和生酮作用受到刺激。这种刺激代表了对压力和禁食的一种重要生理适应。当生长激素增加脂肪分解的能力被阻断时，生长激素对葡萄糖代谢的蛋白质保留和胰岛素拮抗作用要么被消除，要么显著减弱，这与脂肪分解在协调生长激素的代谢作用中起关键作用相一致。