Turnberg Daniel, Botto Marina
Rheumatology Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Mol Immunol. 2003 Sep;40(2-4):145-53. doi: 10.1016/s0161-5890(03)00110-x.
The complement system is very tightly regulated by fluid-phase and membrane-bound factors that prevent injury to self-tissues. The study of genetically engineered animals with targeted deletion or gain of function mutations has highlighted the important role that many of the complement inhibitors play in vivo. The advantages and disadvantages of this type of approach are discussed and the insights gained from the investigation of these animals are reviewed.
补体系统受到液相和膜结合因子的严格调控，这些因子可防止自身组织受到损伤。对具有靶向缺失或功能获得性突变的基因工程动物的研究突出了许多补体抑制剂在体内所起的重要作用。本文讨论了这种方法的优缺点，并综述了对这些动物研究中获得的见解。
