Hanus Lumír, Avraham Yosefa, Ben-Shushan Dikla, Zolotarev Olga, Berry Elliot M, Mechoulam Raphael
Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University, Ein Kerem Campus, Jerusalem 91120, Israel.
Brain Res. 2003 Sep 5;983(1-2):144-51. doi: 10.1016/s0006-8993(03)03046-4.
2-Arachidonoyl glycerol (2-AG) levels in whole mouse brain and two of its regions-hippocampus and hypothalamus-were determined after diet restriction (between 60 and 40%) lasting 12 days. The diet restriction lowered the level of 2-AG, which in the hypothalamus depended on the severity of the diet restriction, while the level in the hippocampus was not dependent on the diet regimen. As these observations differ from previously published data showing elevation of 2-AG levels in rat brain after 24 h of severe food restriction, we measured 2-AG levels in whole mouse brain after a comparable period of full starvation (fasting). We confirmed the elevation of 2-AG levels. It seems possible that these time-dependent variations of 2-AG levels may be of importance as a general coping strategy by animals during periods of starvation.
在持续12天的饮食限制（60%至40%）后，测定了全小鼠脑及其两个区域——海马体和下丘脑——中的2-花生四烯酸甘油酯（2-AG）水平。饮食限制降低了2-AG的水平，其中下丘脑的2-AG水平取决于饮食限制的严重程度，而海马体中的水平则不依赖于饮食方案。由于这些观察结果与之前发表的数据不同，之前的数据显示严重食物限制24小时后大鼠脑中2-AG水平升高，因此我们在可比的完全饥饿（禁食）期后测量了全小鼠脑中的2-AG水平。我们证实了2-AG水平的升高。2-AG水平的这些时间依赖性变化作为动物在饥饿期间的一种普遍应对策略可能具有重要意义。
