Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, Italy.
Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden.
Int J Mol Sci. 2021 Jan 1;22(1):398. doi: 10.3390/ijms22010398.
Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.
不同的神经调节系统参与长期的能量平衡和体重调节，其中有证据表明，内源性大麻素系统，特别是 1 型大麻素受体的激活，起着关键作用。我们在这里回顾了当前的文献，重点介绍了基因编码 1 型大麻素受体在中枢神经系统中的作用，以及食物摄入和特定进食行为对其表达的调节。我们指出，进一步研究环境线索如何通过该基因的转录调节在肥胖和饮食失调的发展中发挥作用，以预防或治疗这些疾病，这一点非常重要。
