Golpe Rafael, Mateos Alfonso, Pérez-Valcárcel Javier, Lapeña José A, García-Figueiras Roberto, Blanco Joaquín
Respiratory, Pathology and Gastroenterology Sections and Radiology Service, Monforte De Lemos Hospital, Lugo, Spain.
Respiration. 2003 May-Jun;70(3):306-9. doi: 10.1159/000072015.
Crohn's disease (CD) can be associated with respiratory involvement. Multiple pulmonary nodules are an infrequent finding in patients with CD. When they are found, histology usually shows sterile necrobiotic nodules, which are spherical aggregates of neutrophils, which frequently cavitate. We report a patient with inactive CD treated with mesalazine, who presented with multiple pulmonary nodules. Transthoracic biopsy of one of the nodules disclosed a benign, nongranulomatous inflammatory lymphoid infiltration. The radiographic abnormalities responded well to oral prednisone. Focal, nongranulomatous lymphoid infiltration thus must be considered in the differential diagnosis of multiple pulmonary nodules in patients with CD.
克罗恩病（CD）可伴有呼吸系统受累。多发性肺结节在CD患者中并不常见。当发现此类结节时，组织学检查通常显示为无菌性坏死结节，即中性粒细胞的球形聚集体，且常发生空洞形成。我们报告一例接受美沙拉嗪治疗的静止期CD患者，该患者出现了多发性肺结节。对其中一个结节进行经胸活检，结果显示为良性、非肉芽肿性炎性淋巴浸润。影像学异常对口服泼尼松反应良好。因此，在CD患者多发性肺结节的鉴别诊断中，必须考虑局灶性、非肉芽肿性淋巴浸润。
