Kalra Veena, Dua Tarun, Kumar Virender
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
J Pediatr. 2003 Jul;143(1):111-4. doi: 10.1016/S0022-3476(03)00211-7.
To determine the efficacy of albendazole plus dexamethasone in children with 1 or 2 ring-enhancing lesions (by computed tomography scan) on resolution of lesions and recurrence of seizure.
Randomized controlled open trial.
Children of either sex, 1 to 14 years of age, with seizures and 1 or 2 ring-enhancing lesions <20 mm in diameter on computed tomography scan, likely to have neurocysticercosis, were assigned to treatment l groups. Children assigned to the treatment group (n=61) were given 0.15 mg/kg per day dexamethasone for 5 days plus 15 mg/kg per day albendazole for 28 days, starting on the third day of dexamethasone. Control group (n=62) children were given neither dexamethasone or albendazole. Anti-epileptic therapy was given to both the study groups.
The lesions resolved completely or partially in more children in the treated group compared with the control group (79% versus 57%; P=.02). The proportion of children who had seizures was significantly lower in the treated group compared with the control group at 3 months (10% versus 32%; P=.006) and 6 months (13% versus 33%; P=.03).
Albendazole plus dexamethasone increased complete or partial resolution of lesions and reduced the risk of subsequent recurrence of seizures among children with neurocysticercosis who had with seizures and 1 or 2 ring-enhancing lesions on computed tomography.
确定阿苯达唑联合地塞米松对患有1个或2个环形强化病灶（通过计算机断层扫描）的儿童病灶消退及癫痫复发的疗效。
随机对照开放试验。
年龄在1至14岁、患有癫痫且计算机断层扫描显示有1个或2个直径<20毫米的环形强化病灶、可能患有神经囊尾蚴病的儿童被分配到治疗组。分配到治疗组的儿童（n = 61）从地塞米松治疗的第三天开始，给予0.15毫克/千克/天的地塞米松，共5天，外加15毫克/千克/天的阿苯达唑，共28天。对照组（n = 62）的儿童既未给予地塞米松也未给予阿苯达唑。两个研究组均给予抗癫痫治疗。
与对照组相比，治疗组中更多儿童的病灶完全或部分消退（79%对57%；P = .02）。在3个月时（10%对32%；P = .006）和6个月时（13%对33%；P = .03），治疗组癫痫发作儿童的比例显著低于对照组。
对于计算机断层扫描显示有癫痫发作且有1个或2个环形强化病灶的神经囊尾蚴病儿童，阿苯达唑联合地塞米松可提高病灶的完全或部分消退率，并降低后续癫痫复发的风险。
