Rossi R, Tommaselli A P, Panza N, Ghiggi M R, Rezza G, Giuliani M, Suligoi B, De Mercato R, Lombardi G
Cattedra di Endocrinologia, II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
J Endocrinol Invest. 1992 Dec;15(11):849-52. doi: 10.1007/BF03348818.
A case of Cushing's syndrome in a 24-yr-old homosexual with an AIDS-related complex is reported. In this patient certain symptoms common to both diseases, i.e. weakness, myalgia and muscle atrophy were accentuated, whereas other symptoms pathognomic of the human immunodeficiency virus (HIV) infection, i.e. lymphoadenopathies and weight loss, were less pronounced by the high levels of circulating adrenal steroids. Ketoconazole was administered po in order to block adrenal steroidogenesis, the drug caused a remarkable fall of cortisol serum concentrations, but was unable to modify significantly the immunological pattern of the patient. Our data suggest that changes of serum adrenal steroid levels have little effect on the immune network of patients with AIDS.
报告了一例24岁患有艾滋病相关综合征的同性恋男性库欣综合征病例。该患者身上两种疾病共有的某些症状，如虚弱、肌痛和肌肉萎缩加剧，而其他人类免疫缺陷病毒（HIV）感染的特征性症状，如淋巴结病和体重减轻，因循环肾上腺类固醇水平升高而不太明显。口服酮康唑以阻断肾上腺类固醇生成，该药物使血清皮质醇浓度显著下降，但未能显著改变患者的免疫模式。我们的数据表明，血清肾上腺类固醇水平的变化对艾滋病患者的免疫网络影响很小。
