Vajrabhaya La-Ongthong, Benjasupattananan Supranee, Sappayatosok Kraisorn, Sirikururat Papatpong, Korsuwannawong Suwanna, Dechosilpa Vittawin
College of Dental Medicine, Rangsit University, Pathumthani 12000, Thailand.
Research Office, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand.
Dent J (Basel). 2025 Aug 15;13(8):369. doi: 10.3390/dj13080369.
: This study evaluates the effectiveness of a toothpaste containing Java Tea and Little Ironweed in alleviating tooth sensitivity compared to a conventional potassium nitrate toothpaste. : A total of 90 healthy patients aged 18-70 with up to two teeth exhibiting gingival recession were recruited into this study. All selected teeth had a visual analog scale (VAS) score ≥ 4 in response to tactile or air blast stimuli. Excluded teeth included those requiring restoration or participants undergoing treatments affecting sensitivity or taking pain medication/anti-sensitivity agents. Participants were randomly divided into three groups and instructed to brush twice daily with different toothpastes. The S1 group was prescribed toothpaste containing Java Tea and Little Ironweed extract, the S2 group was prescribed toothpaste containing Java Tea and Little Ironweed extract with 0.7% potassium nitrate, and the S3 group was prescribed toothpaste containing potassium nitrate. VAS scores were recorded at baseline, 2 weeks, and 4 weeks. Data were then compared and statistically analyzed between the groups. : For the tactile test, the final number of included teeth was 47 in the S1 group, 46 in the S2 group, and 22 in the S3 group. For the air blast test, the number of teeth included was 38 in the S1 group, 30 in the S2 group, and 27 in the S3 group. At baseline, mean VAS scores were comparable across groups for both tactile (S1: 6.89 ± 0.98; S2: 6.65 ± 1.52; S3: 6.82 ± 1.99) and air blast tests (S1: 7.39 ± 1.15; S2: 7.53 ± 1.31; S3: 6.89 ± 2.12). All groups showed significant reductions in VAS scores from baseline at both 2 and 4 weeks. A Kruskal-Wallis test indicated significant between-group differences in VAS scores at 2 and 4 weeks ( = 0.001). Post hoc analysis (Dunn's test with Bonferroni correction) at 2 weeks revealed that the S1 group had significantly higher VAS scores than those of S2 (tactile = 0.001, air blast = 0.001) and S3 (tactile = 0.002, air blast = 0.018). By 4 weeks, the S2 group demonstrated superior efficacy, with significantly lower VAS scores compared to those of S1 (tactile < 0.001, air blast = 0.030) and S3 (tactile = 0.035, air blast = 0.001). : All tested toothpastes effectively reduced dentin hypersensitivity over the study period. Potassium nitrate toothpaste provided more rapid initial relief, when compared to the herbal formulation alone; however, both achieved similar outcomes by 4 weeks. The herbal toothpaste supplemented with potassium nitrate demonstrated superior efficacy and may offer a promising natural alternative for managing dentin hypersensitivity.
本研究评估了一种含有爪哇茶和大蓟的牙膏与传统硝酸钾牙膏相比，在缓解牙齿敏感方面的有效性。本研究招募了90名年龄在18 - 70岁之间、至多两颗牙齿出现牙龈退缩的健康患者。所有入选牙齿在受到触觉或吹气刺激时视觉模拟量表（VAS）评分≥4。排除的牙齿包括那些需要修复的牙齿，或正在接受影响敏感性的治疗、服用止痛药/抗敏感剂的参与者。参与者被随机分为三组，并被指示每天用不同的牙膏刷牙两次。S1组使用含有爪哇茶和大蓟提取物的牙膏，S2组使用含有爪哇茶和大蓟提取物以及0.7%硝酸钾的牙膏，S3组使用含有硝酸钾的牙膏。在基线、2周和4周时记录VAS评分。然后对组间数据进行比较和统计分析。对于触觉测试，S1组纳入牙齿的最终数量为47颗，S2组为46颗，S3组为22颗。对于吹气测试，S1组纳入牙齿数量为38颗，S2组为30颗，S3组为27颗。在基线时，触觉测试（S1：6.89±0.98；S2：6.65±1.52；S3：6.82±1.99）和吹气测试（S1：7.39±1.15；S2：7.53±1.31；S3：6.89±2.12）各组间的平均VAS评分具有可比性。所有组在2周和4周时VAS评分均较基线时有显著降低。Kruskal - Wallis检验表明，在2周和4周时VAS评分存在显著的组间差异（P = 0.001）。2周时的事后分析（采用Bonferroni校正的Dunn检验）显示，S1组的VAS评分显著高于S2组（触觉P = 0.001，吹气P = 0.001）和S3组（触觉P = 0.002，吹气P = 0.018）。到4周时，S2组显示出更好的疗效，其VAS评分显著低于S1组（触觉P < 0.001，吹气P = 0.030）和S3组（触觉P = 0.035，吹气P = 0.001）。在研究期间，所有测试牙膏均有效降低了牙本质过敏。与单独的草药配方相比，硝酸钾牙膏能更快地提供初始缓解；然而，到4周时两者取得了相似的结果。添加了硝酸钾的草药牙膏显示出更好的疗效，可能为管理牙本质过敏提供一种有前景的天然替代品。
