[Expression of tenascin in human nasal polyp tissue and primary studies of its clinical significance].

OBJECTIVE

To explore the pathogenesis of nasal polyposis and the expression of tenascin in human nasal polyps.

METHOD

Tenascin in nasal polyp tissues from twenty-four polyposis patients and tenascin in inferior turbinates tissues from fifteen chronic hypertrophic rhinitis patients were detected with immunohistochemistry (sp) method. The inferior turbinate mucosa of five healthy volunteers were selected as control.

RESULT

Tenascin were expressed in the mucosa epithelial cells and serous cells from nasal polyps and inferior turbinates of chronic hypertrophic rhinitis; The level of tenascin in the mucosa epithelial cells from nasal polyps were significantly(P < 0.01); The level of tenascin in the serous cells from nasal polyps were significantly higher than that in inferior turbinates of chronic hypertrophic rhinitis(P < 0.01); Tenascin were hardly detected in nasal mucosa from healthy volunteers; The tenascin positivity in glandular cell was significantly higher in nasal polyps than in inferior turbinates of chronic hypertrophic rhinitis (P < 0.05).

CONCLUSION

There is close relationship between tenascin and nasal polyps. Tenascin is strongly expressed in nasal polyps and its mucosa, where it could be produced by mucosa epithelial cells and serous cells.