McGeary Ross P, Olive Colleen, Toth Istvan
School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland, Australia.
J Pept Sci. 2003 Jul;9(7):405-18. doi: 10.1002/psc.467.
This review discusses various issues regarding vaccines; what are they and how they work, safety aspects, the role of adjuvants and carriers in vaccination, synthetic peptides as immunogens, and new technologies for vaccine development and delivery including the identification of novel adjuvants for mucosal vaccine delivery. There has been a recent increase of interest in the use of lipids and carbohydrates as adjuvants, and so a particular emphasis is placed on adjuvants derived from lipids or carbohydrates, or from both.
本综述讨论了与疫苗相关的各种问题；疫苗是什么以及它们如何发挥作用、安全性方面、佐剂和载体在疫苗接种中的作用、作为免疫原的合成肽，以及疫苗开发和递送的新技术，包括用于粘膜疫苗递送的新型佐剂的鉴定。最近，人们对使用脂质和碳水化合物作为佐剂的兴趣有所增加，因此特别强调源自脂质或碳水化合物或两者的佐剂。
