Cooper A J, Cernovsky Z, Magnus R V
St. Thomas Psychiatric Hospital, Ontario, Canada.
J Sex Marital Ther. 1992 Winter;18(4):292-302. doi: 10.1080/00926239208412854.
This investigation reports the long-term use of the antiandrogen cyproterone acetate (CPA) in a pedophile, who was studied continuously over 38 months. Measures of sexual arousal, serum testosterone, and gonadotropin levels were significantly reduced by the drug as compared with placebo and no treatment; prolactin levels were significantly elevated. Some workers have observed that long-term administration of CPA (more than one year, which was then discontinued) produced enduring (in some cases apparently permanent) anti-libidinal effects; however, in the case described, within three weeks of stopping the drug, all measures had returned to pretrial levels. The importance of continuous long-term monitoring in sex offenders receiving an antiandrogen is discussed.
本研究报告了一名恋童癖者长期使用抗雄激素醋酸环丙孕酮（CPA）的情况，该患者在38个月内持续接受研究。与安慰剂和未治疗相比，该药物显著降低了性唤起、血清睾酮和促性腺激素水平；催乳素水平显著升高。一些研究人员观察到，长期服用CPA（超过一年，随后停药）会产生持久的（在某些情况下显然是永久性的）性欲抑制作用；然而，在本病例中，停药三周内，所有指标均恢复到治疗前水平。本文讨论了在接受抗雄激素治疗的性犯罪者中进行持续长期监测的重要性。
