Wincze J P, Bansal S, Malamud M
Arch Sex Behav. 1986 Aug;15(4):293-305. doi: 10.1007/BF01550364.
Three chronic pedophiliac sex offenders were treated individually with medroxyprogesterone acetate (MPA) over a minimum of 3 months. Genital and subjective response to erotic stimulation, nocturnal penile tumescence, self-reporting of sexual urges, and testosterone levels were recorded repeatedly throughout the study. A single-subject reversal design was used and medication was administered through a double-blind procedure. The results showed that self-report of arousal outside of a laboratory setting was unreliable as a measure of the drug effect. In a laboratory setting, however, there appeared to be a significant reduction in the report of arousal to erotic stimuli while genital arousal decreased only slightly. Reversal of these responses occurred in only one subject during a final placebo phase. Nocturnal penile tumescence was significantly decreased during MPA administration and appeared to be related to decreases in total testosterone.
三名慢性恋童癖性犯罪者分别接受醋酸甲羟孕酮（MPA）治疗，疗程至少3个月。在整个研究过程中，反复记录对性刺激的生殖器和主观反应、夜间阴茎勃起、性冲动的自我报告以及睾酮水平。采用单受试者反转设计，并通过双盲程序给药。结果表明，在实验室环境之外的性唤起自我报告作为药物效果的衡量指标并不可靠。然而，在实验室环境中，对性刺激的性唤起报告似乎显著减少，而生殖器性唤起仅略有下降。在最后的安慰剂阶段，只有一名受试者出现了这些反应的反转。在服用MPA期间，夜间阴茎勃起显著减少，似乎与总睾酮水平的降低有关。
