Okura T, Koda M, Ando F, Niino N, Ohta S, Shimokata H
Department of Epidemiology, National Institute for Longevity Sciences, Gengo Morioka-cho Obu Aichi, Japan.
Int J Obes Relat Metab Disord. 2003 Sep;27(9):1020-7. doi: 10.1038/sj.ijo.0802378.
To examine whether polymorphisms of the estrogen receptor (ER) alpha gene are associated with body fat distribution.
Cross-sectional, epidemiological study of two single-nucleotide polymorphisms, a T --> C (PvuII) and an A --> G (XbaI), in the first intron of the ERalpha gene.
A total of 2238 community-dwelling middle-aged and elderly Japanese population (age: 40-79 y).
The ERalpha genotypes (by automated fluorescent allele-specific DNA primer assay system), anthropometric variables, fat mass (FM) and percentage FM (%FM) (by dual-energy X-ray absorptiometry).
FM and waist were inversely associated with age (r=-0.630 and -0.504, respectively) in women with the GG genotype. On the other hand, waist circumference of the AA genotype was positively correlated with age (r=0.231). Thus, for middle-aged women (40-59 y) with the AG or GG genotype body mass index (BMI), %FM, FM, waist, hip and waist-to-hip ratio (WHR) were larger than those with the AA genotype. In particular, FM and waist were greater by 20% and 9%, respectively, for the GG genotype, compared to the AA genotype. Alternatively, FM and waist were smaller by 18% and 6%, respectively, in older women with the GG genotype, compared to the AA genotype. No effect was found among the A --> G polymorphisms for men. For both genders, no difference was found in any variables among the TT, TC and CC genotypes with the exception of BMI of older men (60-79 y).
No association was found between the ERalpha gene polymorphisms and body fat distribution in men. For women, the A --> G polymorphism, in particular the GG genotype, may contribute to the development of upper-body obesity in middle-aged individuals, but may serve to decrease the whole-body and abdominal fat tissue of older individuals.
研究雌激素受体（ER）α基因多态性是否与体脂分布相关。
对ERα基因第一个内含子中的两个单核苷酸多态性（一个T→C（PvuII）和一个A→G（XbaI））进行横断面流行病学研究。
总共2238名居住在社区的日本中老年人群（年龄：40 - 79岁）。
ERα基因型（通过自动荧光等位基因特异性DNA引物检测系统）、人体测量变量、脂肪量（FM）和脂肪量百分比（%FM）（通过双能X线吸收法）。
在GG基因型的女性中，FM和腰围与年龄呈负相关（r分别为 - 0.630和 - 0.504）。另一方面，AA基因型的腰围与年龄呈正相关（r = 0.231）。因此，对于40 - 59岁具有AG或GG基因型的中年女性，其体重指数（BMI）、%FM、FM、腰围、臀围和腰臀比（WHR）均高于AA基因型的女性。特别是，与AA基因型相比，GG基因型的FM和腰围分别高出20%和9%。或者，与AA基因型相比，GG基因型的老年女性的FM和腰围分别小18%和6%。在男性中，A→G多态性未发现有影响。对于男女两性，除老年男性（60 - 79岁）的BMI外，TT、TC和CC基因型在任何变量上均未发现差异。
未发现ERα基因多态性与男性体脂分布之间存在关联。对于女性，A→G多态性，特别是GG基因型，可能有助于中年个体上身肥胖的发展，但可能有助于减少老年个体的全身和腹部脂肪组织。
