Krakowiak Jan, Raczkiewicz Dorota, Humeniuk Ewa, Wdowiak Artur, Wróbel Andrzej, Bojar Iwona
Department of Social Medicine, Medical University of Lodz, Żeligowskiego 7/9 Street, 90-752 Łódź, Poland.
Department of Medical Statistics, School of Public Health, Center of Postgraduate Medical Education, Kleczewska 61/63 Street, 01-826 Warsaw, Poland.
Metabolites. 2022 Jul 22;12(8):673. doi: 10.3390/metabo12080673.
The study aimed to investigate the association between the estrogen receptor alpha (ERα) polymorphism and the prevalence of metabolic syndrome (MetS) and obesity, as well as the coexistence of MetS and obesity, in peri- and post-menopausal Polish women. The study group consisted of 202 peri-menopausal and 202 post-menopausal women. ERα polymorphism: Xba I and Pvu II, MetS, BMI, and serum estrogen concentration were analyzed. MetS was found in 29% of the peri-menopausal women and in 21% of the post-menopausal women. BMI did not significantly differ between the peri- and post-menopausal women (≈42% were normal weight, ≈40% were overweight, and ≈18% were obese), ( = 0.82). Serum estrogen concentration in the peri-menopausal women was 91 ± 75 pg/mL, while that in the post-menopausal women was 17 ± 9. pg/mL, on average. Peri-menopausal women with AA and TT genotypes of the ERα polymorphism have a lower risk of obesity and MetS and the co-existence of obesity and MetS, whereas those women with the G or C allele have a higher risk of those health problems.
该研究旨在调查波兰围绝经期和绝经后女性中雌激素受体α（ERα）基因多态性与代谢综合征（MetS）及肥胖症患病率之间的关联，以及MetS与肥胖症的共存情况。研究组由202名围绝经期女性和202名绝经后女性组成。对ERα基因多态性（Xba I和Pvu II）、MetS、体重指数（BMI）和血清雌激素浓度进行了分析。发现29%的围绝经期女性和21%的绝经后女性患有MetS。围绝经期和绝经后女性的BMI无显著差异（约42%体重正常，约40%超重，约18%肥胖），（P = 0.82）。围绝经期女性血清雌激素浓度平均为91±75 pg/mL，而绝经后女性平均为17±9 pg/mL。ERα基因多态性为AA和TT基因型的围绝经期女性患肥胖症、MetS以及肥胖症与MetS共存的风险较低，而携带G或C等位基因的女性患这些健康问题的风险较高。
