Cassar K, Bachoo P, Brittenden J
Department of Vascular Surgery, University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, U.K.
Eur J Vasc Endovasc Surg. 2003 Aug;26(2):130-6. doi: 10.1053/ejvs.2002.1929.
intermittent claudication is associated with a significant reduction in quality of life. Treatment of claudicants aims to reduce mortality from cardio- and cerebro-vascular events and to improve quality of life. Quality of life assessment should be used to guide and evaluate treatment in this group of patients. Peripheral percutaneous transluminal angioplasty (PTA) is now widely used in the treatment of intermittent claudication. The aim of this review is to examine the effect of PTA on quality of life (QOL) in patients with intermittent claudication.
a review was conducted of prospective clinical trials assessing the effect of peripheral PTA on QOL. Publications were retrieved by searching Medline and PreMedline, EMBASE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of systematic reviews, AMED and CINAHL. The reference lists of the relevant publications were also searched.
seven prospective studies (10 publications) on the effect of PTA on QOL in claudicants were identified. Several different questionnaires were used to measure quality of life (Nottingham Health Profiile, SF-36, EuroQol) none of which were disease specific. All the studies showed some improvement in QOL after PTA at follow-up periods of between 6 weeks and 24 months, except for one which showed some improvement at 6 months but not at 24 months.
despite the fact that studies on the effect of PTA on QOL in claudicants have used generic QOL questionnaires which are relatively insensitive, the findings suggest that PTA may result in some improvement in QOL in these patients, although level I evidence to support this is lacking. The availability of disease-specific questionnaires should enable a more accurate assessment of PTA on QOL in these patients.
间歇性跛行与生活质量显著下降相关。间歇性跛行患者的治疗旨在降低心血管和脑血管事件导致的死亡率，并提高生活质量。生活质量评估应用于指导和评估该组患者的治疗。周围血管经皮腔内血管成形术（PTA）目前广泛用于间歇性跛行的治疗。本综述的目的是研究PTA对间歇性跛行患者生活质量（QOL）的影响。
对评估周围血管PTA对QOL影响的前瞻性临床试验进行综述。通过检索医学文献数据库（Medline）和医学预印本数据库（PreMedline）、荷兰医学文摘数据库（EMBASE）、Cochrane对照试验中心注册库、Cochrane系统评价数据库、联合和补充医学数据库（AMED）以及护理学与健康领域数据库（CINAHL）获取相关出版物。还检索了相关出版物的参考文献列表。
确定了7项关于PTA对间歇性跛行患者QOL影响的前瞻性研究（10篇出版物）。使用了几种不同的问卷来测量生活质量（诺丁汉健康概况、SF-36、欧洲五维度健康量表），这些问卷均非针对特定疾病。所有研究均显示，在6周至24个月的随访期内，PTA治疗后QOL有所改善，但有一项研究显示在6个月时有改善，而在24个月时未改善。
尽管关于PTA对间歇性跛行患者QOL影响的研究使用的是相对不敏感的通用QOL问卷，但研究结果表明，PTA可能使这些患者的QOL有所改善，尽管缺乏支持这一结论的I级证据。特定疾病问卷的可用性应能更准确地评估PTA对这些患者QOL的影响。
