Annessi G, Cimitan A, Zambruno G, Di Silverio A
Clinica Dermatologica, Università di Modena, Italy.
Mycoses. 1992 Sep-Oct;35(9-10):243-6. doi: 10.1111/j.1439-0507.1992.tb00855.x.
A 54-year-old man, affected by pemphigus vulgaris and severe steroid-induced diabetes, developed seven red-brown, firm, slightly raised 0.1-1 cm papular lesions on the anterior aspect of both knees and thighs. A cutaneous biopsy showed a granulomatous infiltrate with numerous fungal elements scattered in the dermis and also within giant cells. Cultures of cutaneous biopsy fragments on Sabouraud glucose agar in presence of chloramphenicol resulted in the growth of dark-green colonies at 25 degrees C. They were identified as typical Cladosporium cladosporioides. As far as we know, this species was previously isolated only in an HIV-seropositive patient as opportunistic pathogen in the site of skin testing.
一名54岁男性，患有寻常型天疱疮和严重的类固醇诱导的糖尿病，在双膝关节和大腿前侧出现了7个红棕色、质地坚硬、略隆起的0.1 - 1厘米丘疹性病变。皮肤活检显示有肉芽肿浸润，真皮内及巨细胞内散在大量真菌成分。在含有氯霉素的沙氏葡萄糖琼脂上对皮肤活检组织碎片进行培养，在25摄氏度时长出了深绿色菌落。它们被鉴定为典型的枝孢霉。据我们所知，该菌种此前仅在一名HIV血清阳性患者中作为皮肤试验部位的机会性病原体被分离出来。
