Romano C, Fimiani M, Pellegrino M, Valenti L, Casini L, Miracco C, Faggi E
Istituto di Clinica Dermosifilopatica, Università degli Studi di Siena, Italy.
Mycoses. 1996 May-Jun;39(5-6):211-5. doi: 10.1111/j.1439-0507.1996.tb00127.x.
A 50-year-old gardener with a 3-year history of pemphigus vulgaris and steroid-induced diabetes complained of various papulonodular lesions on the left elbow. The lesions had appeared 11 months previously. Skin biopsy showed chronic granulomatous inflammation of the dermis which contained septate hyphae and large spores mainly free. Fragments of the biopsy specimen, cultured on Sabouraud glucose agar without cycloheximide, for 4 days, produced soft white colonies which later turned blackish brown, especially on the underside. On the basis of the microscopic characters of the conidiophores and conidia, Alternaria tenuissima was identified. This phaeohyphomycete has only been isolated previously in two other cases in Italy.
一名患有寻常型天疱疮和类固醇诱导型糖尿病3年的50岁园丁，主诉左肘部出现各种丘疹结节性病变。这些病变于11个月前出现。皮肤活检显示真皮有慢性肉芽肿性炎症，其中含有分隔菌丝和主要游离的大孢子。将活检标本的碎片接种在不含放线菌酮的沙氏葡萄糖琼脂上培养4天，产生了柔软的白色菌落，随后变为黑褐色，尤其是在底部。根据分生孢子梗和分生孢子的微观特征，鉴定为细极链格孢。这种暗色丝孢霉此前仅在意大利的另外两例病例中分离出。
