Zhao S Z, Papathanasopoulou P, Long Q, Marshall I, Xu X Y
Department of Chemical Engineering and Chemical Technology, Imperial College, London, United Kingdom.
Ann Biomed Eng. 2003 Sep;31(8):962-71. doi: 10.1114/1.1590664.
A combined magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) modeling study was carried out for pulsatile flow in a carotid bifurcation phantom. The aim of the study was to quantify differences in flow patterns between MRI measurement and MRI-based CFD simulations and to further explore the potential for in vivo applications. The computational model was reconstructed from high resolution magnetic resonance (MR) scans. Velocities derived from phase-contrast MR measurements were used as boundary conditions for the CFD calculation. Detailed comparisons of velocity patterns were made between the CFD results and MRI measurements. Good agreement was achieved for the main velocity component in both well-behaved flow (in the common carotid) and disturbed region (in the carotid sinus). Comparison of in-plane velocity vectors showed less satisfactory consistency and revealed that the MR measurements obtained were inadequate to depict the secondary flow pattern as expected. It can be concluded that the combined MRI/CFD is expected to provide more reliable information about the full three-dimensional velocity field.
针对颈动脉分叉模型中的脉动流开展了一项磁共振成像（MRI）与计算流体动力学（CFD）建模相结合的研究。该研究的目的是量化MRI测量结果与基于MRI的CFD模拟之间的流动模式差异，并进一步探索其在体内应用的潜力。计算模型由高分辨率磁共振（MR）扫描重建而成。从相位对比MR测量中得出的速度用作CFD计算的边界条件。对CFD结果与MRI测量结果之间的速度模式进行了详细比较。在表现良好的流动区域（颈总动脉）和紊乱区域（颈动脉窦），主要速度分量均取得了良好的一致性。平面内速度矢量的比较显示出不太令人满意的一致性，并表明所获得的MR测量结果不足以按预期描绘二次流动模式。可以得出结论，MRI/CFD相结合有望提供有关完整三维速度场的更可靠信息。
