Siogkas Panagiotis K, Papafaklis Michail I, Sakellarios Antonis I, Stefanou Kostas A, Bourantas Christos V, Athanasiou Lambros S, Exarchos Themis P, Naka Katerina K, Michalis Lampros K, Parodi Oberdan, Fotiadis Dimitrios I
Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science, University of Ioannina, 45110 Ioannina, Greece.
Department of Cardiology, Medical School, University of Ioannina, 45110 Ioannina, Greece ; Harvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; Michailideion Cardiac Center, University of Ioannina, 45110 Ioannina, Greece.
Biomed Res Int. 2015;2015:628416. doi: 10.1155/2015/628416. Epub 2015 Mar 1.
Pressure measurements using finite element computations without the need of a wire could be valuable in clinical practice. Our aim was to compare the computed distal coronary pressure values with the measured values using a pressure wire, while testing the effect of different boundary conditions for the simulation. Eight coronary arteries (lumen and outer vessel wall) from six patients were reconstructed in three-dimensional (3D) space using intravascular ultrasound and biplane angiographic images. Pressure values at the distal and proximal end of the vessel and flow velocity values at the distal end were acquired with the use of a combo pressure-flow wire. The 3D lumen and wall models were discretized into finite elements; fluid structure interaction (FSI) and rigid wall simulations were performed for one cardiac cycle both with pulsatile and steady flow in separate simulations. The results showed a high correlation between the measured and the computed coronary pressure values (coefficient of determination [r(2)] ranging between 0.8902 and 0.9961), while the less demanding simulations using steady flow and rigid walls resulted in very small relative error. Our study demonstrates that computational assessment of coronary pressure is feasible and seems to be accurate compared to the wire-based measurements.
使用无需导线的有限元计算进行压力测量在临床实践中可能具有重要价值。我们的目的是将计算得出的冠状动脉远端压力值与使用压力导丝测量的值进行比较，同时测试不同边界条件对模拟的影响。利用血管内超声和双平面血管造影图像，在三维（3D）空间中重建了来自6名患者的8条冠状动脉（管腔和血管外壁）。使用组合压力-流量导丝获取血管远端和近端的压力值以及远端的流速值。将3D管腔和壁模型离散为有限元；在单独的模拟中，针对一个心动周期，分别采用脉动流和稳流进行了流固耦合（FSI）和刚性壁模拟。结果显示，测量值与计算得出的冠状动脉压力值之间具有高度相关性（决定系数[r(2)]在0.8902至0.9961之间），而使用稳流和刚性壁的要求较低的模拟产生的相对误差非常小。我们的研究表明，与基于导丝的测量相比，冠状动脉压力的计算评估是可行的，而且似乎是准确的。
