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Synthesis of the phosphoramidite derivative of 2'-deoxy-2'-C-beta-methylcytidine.

作者信息

Li Nan-Sheng, Piccirilli Joseph A

机构信息

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, University of Chicago, 5841 South Maryland Avenue, MC 1028, Chicago, Illinois 60637, USA.

出版信息

J Org Chem. 2003 Aug 22;68(17):6799-802. doi: 10.1021/jo034263y.

DOI:10.1021/jo034263y
PMID:12919052
Abstract

2'-Deoxy-2'-C-beta-methylnucleosides elicit interest as potential therapeutic agents and as analogues for the analysis of nucleic acid structure and function. An efficient route for the synthesis of 2'-deoxy-2'-C-methyluridine (11), 2'-deoxy-2'-C-methylcytidine (12), and the phosphoramidite derivative of 2'-deoxy-2'-C-beta-methylcytidine (10, 46% overall yield) from 1,2,3,5-tetra-O-benzoyl-2-C-beta-methylribofuranose (1) is described.

摘要

相似文献

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