Commercial-scale synthesis of protected 2'-deoxycytidine and cytidine nucleosides.
作者信息
Divakar Kikkeri J, Sawant Chitra M, Mulla Y A, Zemse Deepak V, Sitabkhan Sakina M, Ross Bruce S, Sanghvi Yogesh S
机构信息
Research and Development, Innovasynth Technologies (India) Limited, (Formerly a Division of Indian Organic Chemicals Limited), Khopoli District, Raigad, Maharashtra, India.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1321-5. doi: 10.1081/NCN-120022956.
PMID:14565409
Abstract
Transformation of 2'-deoxyuridine and uridine analogs to protected 2'-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude that the triazolation method is better and suitable for commercial scale-up.
摘要
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