Isbir T, Yilmaz H, Agachan B, Karaali Z E
Department of Molecular Medicine, Istanbul Istanbul University, Turkey.
Clin Genet. 2003 Sep;64(3):228-34. doi: 10.1034/j.1399-0004.2003.00137.x.
The aim of this study was to compare patients with coronary artery disease (CAD) to healthy objects, in order to explore a possible association between CAD and the variants in the gene encoding cholesterol ester transfer protein (CETP), apolipoprotein E (Apo E) and lipoprotein lipase (LPL). The relationship between CETP MspI, apo E and LPL PvuII gene polymorphisms and serum lipids were investigated in 173 patients with CAD and 111 healthy controls. The frequency of Apo epsilon4 (p < 0.05) and CETP M1 (p < 0.01) alleles were higher in the CAD group than in the control group. In the CAD group, those with the Msp M1 allele had higher levels of total cholesterol (TC) (p = 0026) and low-density lipoprotein cholesterol (LDL-C) than those with the Msp M2 allele. Subjects with an epsilon2 allele had the lowest levels of TC and LDL-C, while subjects with the epsilon4 allele had the highest. In the control group, CETP, the Msp M2 allele was associated with a higher level of high-density lipoprotein cholesterol (HDL-C) (p = 0.012) than the Msp M1 allele. The distributions of LPL genotype and allele did not differ between the CAD and control groups. The present study demonstrates that the CETP Msp1 and Apo E gene polymorphisms are associated with variations in lipids in patients with CAD and healthy controls in Turkish population.
本研究旨在将冠心病（CAD）患者与健康对象进行比较，以探究CAD与胆固醇酯转运蛋白（CETP）、载脂蛋白E（Apo E）和脂蛋白脂肪酶（LPL）编码基因变异之间的可能关联。在173例CAD患者和111例健康对照中，研究了CETP MspI、apo E和LPL PvuII基因多态性与血脂之间的关系。CAD组中Apo epsilon4（p<0.05）和CETP M1（p<0.01）等位基因的频率高于对照组。在CAD组中，携带Msp M1等位基因者的总胆固醇（TC）（p = 0.026）和低密度脂蛋白胆固醇（LDL-C）水平高于携带Msp M2等位基因者。携带epsilon2等位基因的受试者TC和LDL-C水平最低，而携带epsilon4等位基因的受试者水平最高。在对照组中，CETP的Msp M2等位基因与高密度脂蛋白胆固醇（HDL-C）水平高于Msp M1等位基因相关（p = 0.012）。CAD组和对照组之间LPL基因型和等位基因的分布没有差异。本研究表明，在土耳其人群的CAD患者和健康对照中，CETP Msp1和Apo E基因多态性与血脂变化有关。
