Leuridan E, Van Damme P
Centre for the Evaluation of Vaccination, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Vaccine. 2007 Aug 21;25(34):6296-304. doi: 10.1016/j.vaccine.2007.06.020. Epub 2007 Jun 29.
This paper reviews literature on passively transferred maternal antibodies against measles in infants. The amount and decay of these antibodies can be a result of changing patterns in society: increasing cohorts of women are vaccinated against measles instead of having naturally acquired immunity, the age of first childbirth is increasing and young adults are less exposed to natural boosters. The concentration and persistence of maternal antibodies differ in infants of women vaccinated against measles versus infants of naturally immune women. The date for commencing universal measles vaccination should take into account the presence of these antibodies since they can hamper the immunological response to vaccination. Each country should therefore consider adapting the timing of vaccination in relation to its measles sero-epidemiological situation. The possibility of priming the immune system with an early vaccine dose and boosting later on offers opportunities for vaccination at very young age.
本文综述了关于婴儿被动获得的母体抗麻疹抗体的文献。这些抗体的数量和衰减可能是社会模式变化的结果：越来越多的女性接种麻疹疫苗而非自然获得免疫力，初育年龄在增加，年轻人接触自然增强剂的机会减少。接种麻疹疫苗的女性所生婴儿与自然免疫女性所生婴儿体内母体抗体的浓度和持久性有所不同。开始普遍接种麻疹疫苗的日期应考虑到这些抗体的存在，因为它们会妨碍对疫苗接种的免疫反应。因此，每个国家都应根据其麻疹血清流行病学情况考虑调整疫苗接种时间。用早期疫苗剂量启动免疫系统并在后期加强免疫的可能性为在非常年幼时进行疫苗接种提供了机会。
