Lanot R, Cordonnier J L
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Neutral DNA-ase acts as a general teratogen when given to young chicken blastoderms. The rate of the differents abnormalities varies according to the dose given and the embryos' stage. The frequency of the different defects reaches a maximum value with increasing doses it falls generally down with more important doses. DMSO added to the enzyme solution changes the susceptibility of the embryos.
将中性DNA酶施用于幼鸡胚盘时,它会作为一种全身性致畸剂起作用。不同异常情况的发生率会根据给药剂量和胚胎阶段而有所不同。随着给药剂量增加,不同缺陷的发生频率达到最大值;而剂量进一步增大时,该频率通常会下降。添加到酶溶液中的二甲基亚砜会改变胚胎的易感性。