Boudoulas H, Schaal S F, Lewis R P, Welch T G, DeGreen P, Kates R E
Chest. 1977 Feb;71(2):170-5. doi: 10.1378/chest.71.2.170.
The effect of administration of lidocaine on left ventricular performance was studied using systolic time intervals in nine normal subjects, eight patients with stable angina, and 15 patients with acute myocardial infarction. The greatest response in systolic time intervals occurred at three minutes after intravenous injection of lidocaine (100 mg), with values returning to baseline at 10 to 15 minutes. Administration of lidocaine produced a significant prolongation of the preejection period (PEP) corrected for heart rate in all groups and a prolongation of the ratio of PEP to left ventricular ejection time (PEP/LVET) in patients with angina. The group with acute myocardial infarction exhibited a hyperadrenergic state, as shown by a short baseline QS2I. The QS I was lengthened by administration of lidocaine in all groups, but this was more profound in those with acute myocardial infarction. These changes in systolic time intervals were still present at two hours after injection in six patients with acute myocardial infarction in whom an infusion of lidocaine followed the initial bolus. The effect of administering lidocaine after intravenous injection of propranolol (5 mg) was also studied in six normal subjects. Although propranolol therapy along prolonged the PEP/LVET, a further significant prolongation followed subsequent injection of lidocaine.
采用收缩期时间间期，对9名正常受试者、8名稳定型心绞痛患者和15名急性心肌梗死患者进行研究，以探讨利多卡因给药对左心室功能的影响。静脉注射利多卡因（100mg）后三分钟，收缩期时间间期出现最大反应，10至15分钟时数值恢复至基线水平。利多卡因给药使所有组心率校正后的射血前期（PEP）显著延长，使心绞痛患者的PEP与左心室射血时间之比（PEP/LVET）延长。急性心肌梗死组表现为高肾上腺素能状态，如基线QS2I较短。所有组中利多卡因给药均使QS I延长，但在急性心肌梗死患者中更为显著。在初始推注后持续输注利多卡因的6名急性心肌梗死患者中，注射两小时后收缩期时间间期的这些变化仍然存在。还对6名正常受试者研究了静脉注射普萘洛尔（5mg）后给予利多卡因的效果。虽然普萘洛尔治疗也延长了PEP/LVET，但随后注射利多卡因后进一步显著延长。
