Hjortswang Henrik, Järnerot Gunnar, Curman Bengt, Sandberg-Gertzén Hanna, Tysk Curt, Blomberg Björn, Almer Sven, Ström Magnus
Division of Gastroenterology and Hepatology, Linköping University Hospital, Linköping, Sweden.
Eur J Gastroenterol Hepatol. 2003 Sep;15(9):1011-20. doi: 10.1097/00042737-200309000-00012.
The aims of this study were to analyse the health-related quality of life of patients with ulcerative colitis and to assess in what way demographic and disease-related factors influence patients' experiences of this, in order to interpret the results of health-related quality of life assessment more correctly.
We carried out a cross-sectional evaluation of 300 consecutive patients with ulcerative colitis from the catchment areas of Linköping University Hospital and Orebro University Hospital in Sweden. Health-related quality of life was measured using four questionnaires: the IBDQ, the RFIPC, the SF-36 and the PGWB. Disease activity was evaluated using a one-week symptom diary, blood tests and rigid sigmoidoscopy. Demographic factors (gender, age, civil status, educational level), disease-related factors (disease duration, disease extent, disease activity) and presence of co-morbidity were obtained.
Health-related quality of life was mainly impaired in the psychological and social areas and to a much lesser degree in physical areas. Patients with relapse had significantly more disease-related worries and concerns (the RFIPC), more impaired social functioning (the IBDQ and SF-36), and a lower feeling of well being (the IBDQ, the SF-36 and the PGWB). However, their physical function (SF-36) was no worse than patients in remission. Besides the symptom burden of the current disease, co-morbidity and female gender were associated with a lower health-related quality of life.
To correctly interpret health-related quality of life assessments, it is necessary to consider co-morbidity and gender distribution in addition to the symptom burden of the disease studied.
本研究旨在分析溃疡性结肠炎患者的健康相关生活质量，并评估人口统计学和疾病相关因素以何种方式影响患者的这一体验，以便更准确地解读健康相关生活质量评估结果。
我们对瑞典林雪平大学医院和厄勒布鲁大学医院服务区域内连续的300例溃疡性结肠炎患者进行了横断面评估。使用四份问卷测量健康相关生活质量：炎症性肠病问卷（IBDQ）、炎症性肠病患者关注指数（RFIPC）、简短健康调查问卷（SF-36）和总体幸福感量表（PGWB）。通过一周症状日记、血液检查和硬式乙状结肠镜检查评估疾病活动度。获取人口统计学因素（性别、年龄、婚姻状况、教育水平）、疾病相关因素（病程、病变范围、疾病活动度）以及合并症情况。
健康相关生活质量主要在心理和社会领域受损，而在身体领域受损程度要小得多。复发患者有明显更多与疾病相关的担忧（RFIPC）、社会功能受损更严重（IBDQ和SF-36）以及幸福感更低（IBDQ、SF-36和PGWB）。然而，他们的身体功能（SF-36）并不比缓解期患者差。除了当前疾病的症状负担外，合并症和女性性别与较低的健康相关生活质量相关。
为了准确解读健康相关生活质量评估结果，除了所研究疾病的症状负担外，还需要考虑合并症和性别分布情况。
