Hjortswang H, Järnerot G, Curman B, Sandberg-Gertzén H, Tysk C, Blomberg B, Almer S, Ström M
Dept of Gastroenterology and Endocrinology, Linköping University, Sweden.
Scand J Gastroenterol. 2001 Jan;36(1):77-85. doi: 10.1080/00365520150218093.
The Inflammatory Bowel Disease Questionnaire (IBDQ) is a disease-specific health-related quality of life (HRQOL) questionnaire including four dimensions and a sum score. The aim of this study was to assess the internal and external validity, reliability, and sensitivity of a Swedish version of the IBDQ.
Three hundred consecutive patients with ulcerative colitis completed the IBDQ and three other health-related quality of life questionnaires (the Rating Form of IBD Patient Concerns (RFIPC), the Short Form-36 (SF-36) and the Psychological General Well-Being (PGWB) index). Disease activity was evaluated using a 1-week symptom diary, blood tests and rigid sigmoidoscopy. One hundred and fourteen patients filled in the questionnaire a second time, of whom 75 had been in stable remission for over 6 months and 39 had a significant clinical change in disease activity.
Factor analysis of the 32 IBDQ items did not support the four dimensional scores. The dimensional scores had sufficient convergent validity, but low discriminative validity and homogeneity. The homogeneity was also low for the sum score. The inter-dimensional correlations were high. The concurrent validity was supported by correlations between the dimensional scores and other measures of disease activity and HRQOL. Patients in relapse scored significantly less on the sum score and the four dimensions compared to patients in remission. The test-retest correlations for the dimensional scores were 0.40-0.76. Patients with a change in disease activity during the 6-month follow-up period had a significant change in IBDQ scores not found in those who remained in remission.
The Swedish version of the IBDQ had external validity and was shown to be a reliable and sensitive measure of HRQOL in ulcerative colitis, though there are some concerns regarding the internal validity. The use of a sum score was not supported and the questionnaire may benefit from a redivision of items into dimensions with better homogeneity and discriminative validity.
炎症性肠病问卷（IBDQ）是一种针对疾病的健康相关生活质量（HRQOL）问卷，包括四个维度和一个总分。本研究的目的是评估瑞典语版IBDQ的内部和外部效度、信度及敏感性。
连续300例溃疡性结肠炎患者完成了IBDQ及其他三份健康相关生活质量问卷（炎症性肠病患者关注评分表（RFIPC）、简短健康调查问卷36项版（SF - 36）和心理总体幸福感（PGWB）指数）。使用为期1周的症状日记、血液检查和硬性乙状结肠镜检查评估疾病活动度。114例患者再次填写问卷，其中75例病情稳定缓解超过6个月，39例疾病活动度有显著临床变化。
对IBDQ的32个项目进行因子分析不支持四个维度得分。维度得分具有足够的收敛效度，但区分效度和同质性较低。总分的同质性也较低。维度间相关性较高。维度得分与疾病活动度和HRQOL的其他测量指标之间的相关性支持了同时效度。与缓解期患者相比，复发患者的总分和四个维度得分显著更低。维度得分的重测相关性为0.40 - 0.76。在6个月随访期内疾病活动度发生变化的患者，其IBDQ得分有显著变化，而病情仍处于缓解期的患者则未出现这种变化。
瑞典语版IBDQ具有外部效度，被证明是评估溃疡性结肠炎患者HRQOL的可靠且敏感的指标，尽管在内部效度方面存在一些问题。总分的使用未得到支持，该问卷可能受益于将项目重新划分为同质性和区分效度更好的维度。
