由DNA转运马达进行的染色质组装。

Chromatin assembly by DNA-translocating motors.

作者信息

Haushalter Karl A, Kadonaga James T

机构信息

Section of Molecular Biology, University of California, 9500 Gilman Drive, La Jolla, San Diego, California 92093-0347, USA.

出版信息

Nat Rev Mol Cell Biol. 2003 Aug;4(8):613-20. doi: 10.1038/nrm1177.

DOI:10.1038/nrm1177

PMID:12923523

Abstract

Chromatin assembly is required for the duplication of eukaryotic chromosomes and functions at the interface between cell-cycle progression and gene expression. The central machinery that mediates chromatin assembly consists of histone chaperones, which deliver histones to the DNA, and ATP-utilizing motor proteins, which are DNA-translocating factors that act in conjunction with the histone chaperones to mediate the deposition of histones into periodic nucleosome arrays. Here, we describe these factors and propose possible mechanisms by which DNA-translocating motors might catalyse chromatin assembly.

摘要

染色质组装是真核染色体复制所必需的，并且在细胞周期进程与基因表达的界面发挥作用。介导染色质组装的核心机制由组蛋白伴侣组成，组蛋白伴侣将组蛋白传递给DNA，以及利用ATP的马达蛋白，这些蛋白是DNA转运因子，与组蛋白伴侣协同作用，介导组蛋白沉积到周期性核小体阵列中。在这里，我们描述了这些因子，并提出了DNA转运马达可能催化染色质组装的可能机制。