Albertson Donna G, Collins Colin, McCormick Frank, Gray Joe W
Cancer Research Institute, University of California San Francisco, San Francisco, California 94143-0808, USA.
Nat Genet. 2003 Aug;34(4):369-76. doi: 10.1038/ng1215.
Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.
人类实体瘤中的染色体畸变是基因失调和基因组不稳定的标志。本综述总结了关于畸变的现有知识，讨论了它们的功能重要性，提出了在癌症进展过程中畸变可能形成的机制，并提供了来自染色体畸变研究的临床进展实例。
