Aizawa Katsuji, Akimoto Takayuki, Inoue Hironobu, Kimura Fuminori, Joo Mihyun, Murai Fumie, Mesaki Noboru
Doctoral Program in Health and Sport Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, 305-8574, Ibaraki, Japan.
Eur J Appl Physiol. 2003 Nov;90(5-6):575-80. doi: 10.1007/s00421-003-0912-5. Epub 2003 Aug 16.
This study examined changes among young females of resting serum dehydroepiandrosterone sulfate (DHEAS) concentration after an 8-week period of resistance training. Nineteen healthy untrained young females [training group: age 18.9 (0.3) years, n=10, control group: age 19.3 (1.0) years, n=9; mean (SD)] were recruited in this study. The training group participated in an 8-week resistance training program (2 days per week on nonconsecutive days). The control group did not involve in any resistance training or regular exercise during the study period. Muscular strength, anthropometry, and resting hormonal levels were measured before and after training in both groups. Serum concentrations of DHEAS, dehydroepiandrosterone (DHEA), testosterone and cortisol were measured by radioimmunoassay. Body mass (2.4%) and lean body mass (2.4%) were significantly increased in the training group ( P<0.05), but not in the control group. The training also significantly increased one-repetition maximum (1-RM) values ( P<0.05). In the training group, resting concentration of serum DHEAS significantly increased after training ( P<0.05). Percent change of DHEAS in the training group was greater than that of the control group ( P<0.05). In the training group, the change of DHEAS level was positively correlated with the change of lean body mass during the training ( r=0.61; P<0.05). Serum DHEA, testosterone and cortisol concentrations did not change in either group during the training. The dramatic increase of resting serum DHEAS concentration after training indicates that DHEAS might be an anabolic hormone marker of adaptation to resistance training among young females. Results are presented as mean (SD).
本研究检测了年轻女性在进行为期8周的抗阻训练后，静息血清硫酸脱氢表雄酮（DHEAS）浓度的变化。本研究招募了19名未经训练的健康年轻女性[训练组：年龄18.9（0.3）岁，n = 10；对照组：年龄19.3（1.0）岁，n = 9；均值（标准差）]。训练组参加了为期8周的抗阻训练计划（每周2天，非连续进行）。对照组在研究期间未参与任何抗阻训练或常规运动。两组在训练前后均测量了肌肉力量、人体测量指标和静息激素水平。采用放射免疫分析法测定血清DHEAS、脱氢表雄酮（DHEA）、睾酮和皮质醇的浓度。训练组的体重（2.4%）和瘦体重（2.4%）显著增加（P<0.05），而对照组则无显著变化。训练还显著提高了一次重复最大值（1-RM）（P<0.05）。在训练组中，训练后血清DHEAS的静息浓度显著增加（P<0.05）。训练组中DHEAS的变化百分比大于对照组（P<0.05）。在训练组中，训练期间DHEAS水平的变化与瘦体重的变化呈正相关（r = 0.61；P<0.05）。训练期间两组的血清DHEA、睾酮和皮质醇浓度均无变化。训练后静息血清DHEAS浓度的显著增加表明，DHEAS可能是年轻女性适应抗阻训练的一种合成代谢激素标志物。结果以均值（标准差）表示。
