Abbasi A, Duthie E H, Sheldahl L, Wilson C, Sasse E, Rudman I, Mattson D E
Department of Medicine, Medical College of Wisconsin, and Veterans Affairs Medical Center, Milwaukee, USA.
J Am Geriatr Soc. 1998 Mar;46(3):263-73. doi: 10.1111/j.1532-5415.1998.tb01036.x.
To determine the association of dehydroepiandrosterone sulfate (DHEAS), body composition, and physical fitness in independent community-dwelling men and women aged 60 to 80 years.
Cross sectional analysis.
Independent men and women, 60 years of age and older, living in urban and suburban communities of Southeastern Wisconsin.
History, physical examination, physical activity level, and anthropometrics were measured for every subject. Total adipose mass (TAM) and lean body mass were measured using dual energy X-ray absorptiometry. Dehydroepiandrosterone sulfate, insulin-like growth factor-1 (IGF-1), total testosterone (TT), and free testosterone (FT) were measured using radioimmunoassay. Physical fitness was measured as VO2max using exercise stress tests. Blood for lipids was analyzed using standard assays.
In men, the DHEAS was significantly correlated to age (r = -.32), TAM (r = -.27), percent fat (r = -.30), HDL cholesterol (r = .34), TT (r = .30), VO2max (r = .23), and percent lean body mass (% LBM) (r = .33). In women, the DHEAS was not significantly correlated to any of the variables examined except body mass index (BMI) (r = .23). In men, after partialling out age, DHEAS was significantly correlated to HDL, % fat, TAM, % LBM, and TT. Multivariate analysis for men revealed that high density lipoprotein cholesterol (HDL) was the strongest predictor of serum DHEAS level, followed by % LBM, BMI, and age. The men in the highest quartile of serum DHEAS levels were different from those in the lowest quartile in terms of age, TT, FT, % fat, TAM, % LBM, HDL, and low density lipoprotein (LDL) cholesterol level. No such differences were found in the two groups of women.
In this group of independent community-dwelling older men, several factors were found to be associated with the serum DHEAS concentration, whereas in a group of older women, no such associations were identified with the exception of BMI. Men in the highest quartile of serum DHEAS level, compared with those with a serum DHEAS level in the lowest quartile, were younger, leaner, more fit, had higher TT and FT levels, and had a favorable lipid profile. No such differences were identified between the women in the highest and the lowest quartiles of serum DHEAS level.
确定硫酸脱氢表雄酮（DHEAS）、身体成分和体能在年龄60至80岁的独立社区居住男性和女性中的关联。
横断面分析。
年龄60岁及以上，居住在威斯康星州东南部城市和郊区社区的独立男性和女性。
对每位受试者测量病史、体格检查、身体活动水平和人体测量学指标。使用双能X线吸收法测量总脂肪量（TAM）和瘦体重。使用放射免疫分析法测量硫酸脱氢表雄酮、胰岛素样生长因子-1（IGF-1）、总睾酮（TT）和游离睾酮（FT）。使用运动压力测试以最大摄氧量（VO2max）来衡量体能。使用标准检测方法分析血脂血液样本。
在男性中，DHEAS与年龄（r = -0.32）、TAM（r = -0.27）、脂肪百分比（r = -0.30）、高密度脂蛋白胆固醇（r = 0.34）、TT（r = 0.30）、VO2max（r = 0.23）和瘦体重百分比（%LBM）（r = 0.33）显著相关。在女性中，DHEAS除了与体重指数（BMI）（r = 0.23）外，与所检查的任何变量均无显著相关性。在男性中，排除年龄因素后，DHEAS与高密度脂蛋白、脂肪百分比、TAM、%LBM和TT显著相关。男性的多变量分析显示，高密度脂蛋白胆固醇（HDL）是血清DHEAS水平的最强预测因子，其次是%LBM、BMI和年龄。血清DHEAS水平处于最高四分位数的男性与最低四分位数的男性在年龄、TT、FT、脂肪百分比、TAM、%LBM、HDL和低密度脂蛋白（LDL）胆固醇水平方面存在差异。两组女性中未发现此类差异。
在这组独立社区居住的老年男性中，发现有几个因素与血清DHEAS浓度相关，而在一组老年女性中，除BMI外未发现此类关联。血清DHEAS水平处于最高四分位数的男性与血清DHEAS水平处于最低四分位数的男性相比，更年轻、更瘦、更健康，TT和FT水平更高，且血脂谱更佳。血清DHEAS水平最高和最低四分位数的女性之间未发现此类差异。
