Yildiz Hakan, Oncel Mustafa, Kurt Necmi, Vural Selahattin, Gezen Cem, Dalkilic Gulay, Olcay Engin
General Surgery Service, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey.
Ulus Travma Acil Cerrahi Derg. 2003 Jul;9(3):183-8.
The aim of this study is to analyze the relationship between the changes in blood and peritoneal fluid and the duration of mechanical intestinal obstruction.
A mechanical intestinal obstruction was surgically carried out in 52 Wistar albino rats. The blood and peritoneal fluid were sampled immediately (Group 1, n=13), and at 6 hours (Group 2, n=13), at 24 hours (Group 3, n=13), and at 48 hours (Group 4, n=13) following the procedure.
Blood and peritoneal fluid ammonia concentrations, as well as blood aldolase activity have risen progressively over time (p<0.05), although not all pair-wise comparisons were statistically significant (P>0.05).
Our data suggest that peritoneal fluid and blood ammonia levels and blood aldolase levels rise according to duration of the intestinal obstruction. Since the results were not available to determine cut-off levels, future research is required to confirm these results and determine whether ammonia or aldolase can be used in clinical practice to predict the presence and duration of a mechanical intestinal obstruction.
本研究旨在分析血液和腹腔液变化与机械性肠梗阻持续时间之间的关系。
对52只Wistar白化大鼠进行机械性肠梗阻手术。术后立即（第1组，n = 13）、术后6小时（第2组，n = 13）、术后24小时（第3组，n = 13）和术后48小时（第4组，n = 13）采集血液和腹腔液样本。
血液和腹腔液氨浓度以及血液醛缩酶活性随时间逐渐升高（p < 0.05），尽管并非所有两两比较均具有统计学意义（P > 0.05）。
我们的数据表明，腹腔液和血液氨水平以及血液醛缩酶水平随肠梗阻持续时间而升高。由于尚无确定临界值的结果，未来需要开展研究以证实这些结果，并确定氨或醛缩酶是否可用于临床实践中预测机械性肠梗阻的存在及持续时间。
