DeLaurier G A, Cannon R M, Johnson R H, Sisley J F, Baisden C R, Mansberger A R
Department of Surgery, Medical College of Georgia, Augusta 30912.
Am J Surg. 1989 Jul;158(1):32-5. doi: 10.1016/0002-9610(89)90311-5.
In the present study, we determined values for peritoneal fluid and blood ammonia, amylase, and lactic acid content in 11 dogs after experimental bowel strangulation. In the nine survivors of this group, we demonstrated a near linear increase in peritoneal fluid lactic acid over a 24-hour period, during which the plasma lactic acid remained relatively constant. A significant increase in peritoneal fluid ammonia was also demonstrated, but this did not occur until more than 16 hours after strangulation. In a second group of two dogs in which simple obstruction was produced, no significant increase in peritoneal fluid lactic acid or ammonia occurred. We did not find significant changes in peritoneal fluid amylase in this study. These data suggest that the determination of peritoneal fluid lactic acid content, especially when compared with concomitant plasma lactic acid, may be useful in the accurate preoperative diagnosis of bowel strangulation.
在本研究中，我们测定了11只犬在实验性肠绞窄后腹膜液和血液中氨、淀粉酶及乳酸的含量。在该组9只存活犬中，我们发现腹膜液乳酸在24小时内呈近似线性增加，而在此期间血浆乳酸保持相对恒定。腹膜液氨也显著增加，但直到绞窄后16小时以上才出现。在另一组两只造成单纯梗阻的犬中，腹膜液乳酸或氨未出现显著增加。在本研究中，我们未发现腹膜液淀粉酶有显著变化。这些数据表明，测定腹膜液乳酸含量，尤其是与同期血浆乳酸进行比较时，可能有助于准确术前诊断肠绞窄。
