Akgür F M, Kulinç K, Aktuğ T
Department of Pediatric Surgery, Dokuz Eylül University, Medical Faculty, Izmir, Turkey.
Eur J Pediatr Surg. 1993 Apr;3(2):72-4. doi: 10.1055/s-2008-1063514.
Hypoxanthine has been shown to be a sensitive and more specific measure of hypoxia than lactate in several body fluids other than peritoneal fluid. An experimental study was conducted to determine the value of peritoneal fluid hypoxanthine besides lactic acid levels in detecting vascular compromise of the intestine. Thirty male guinea pigs were divided in 3 groups each containing 10 animals. Groups comprised of sham operation control, simple intestinal obstruction and intestinal obstruction with vascular compromise. Lactic acid and hypoxanthine levels were determined in peritoneal lavage effluents. Peritoneal fluid lactic acid levels increased after 4 hours of intestinal obstruction with vascular compromise (p < 0.01) but not in simple intestinal obstruction and sham operation control groups. No detectable amount of hypoxanthine could be found in any of the fluid samples. It is concluded that unlike in other body fluids hypoxanthine is not present in peritoneal fluid and does not become evident after vascular compromise of the intestine.
除了腹腔液外，在其他几种体液中，次黄嘌呤已被证明是一种比乳酸更敏感、更具特异性的缺氧指标。进行了一项实验研究，以确定除乳酸水平外，腹腔液次黄嘌呤在检测肠道血管受损方面的价值。30只雄性豚鼠被分为3组，每组10只。分组包括假手术对照组、单纯肠梗阻组和伴有血管受损的肠梗阻组。测定腹腔灌洗流出液中的乳酸和次黄嘌呤水平。伴有血管受损的肠梗阻4小时后，腹腔液乳酸水平升高（p<0.01），但单纯肠梗阻组和假手术对照组未升高。在任何液体样本中均未检测到次黄嘌呤。结论是，与其他体液不同，腹腔液中不存在次黄嘌呤，肠道血管受损后也不会出现明显变化。
