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[输血事件报告:鹿特丹前ZWN(荷兰西南部)地区血库血液警戒第一年的经验]

[Reports of transfusion incidents: experiences from the first year of hemovigilance in the region of the former ZWN (South West Netherlands) blood bank in Rotterdam].

作者信息

Beckers E A, Dinkelaar R B, te Boekhorst P A, van Ingen H E, van Rhenen D J

机构信息

Sanquin Bloedbank regio Zuidwest, locatie Rotterdam, Wytemaweg 10, 3015 CN Rotterdam.

出版信息

Ned Tijdschr Geneeskd. 2003 Aug 2;147(31):1508-12.

Abstract

OBJECTIVE

Itemize blood transfusion incidents in the South-West Netherlands region (about 3.5 million inhabitants), where a regional reporting system for transfusion incidents was introduced in January 2001.

DESIGN

Prospective, descriptive.

METHOD

In the period 1 January 2001-31 December 2001, 22 hospitals voluntarily reported transfusion incidents in patients to the blood bank. All incidents were anonymously recorded in a standardised report and registered in 14 categories.

RESULTS

A total of 119 transfusion incidents were reported and categorised as: incorrect blood component transfused (n = 8), mild fever 1-2 degrees C (n = 14), non-haemolytic fever > 2 degrees C (n = 36), acute haemolytic transfusion reactions (n = 3). delayed haemolytic transfusion reactions (n = 18), allergic reactions (n = 11), bacterial contamination (n = 3), transfusion-related acute lung injury (n = 1), near accidents (n = 6) and product recalls (n = 19). There were no reports in the categories anaphylactic shock, post-transfusion purpura, transfusion-acquired viral infection, and transfusion-related graft versus host disease. In the same year of haemovigilance, the blood bank issued a total of 158,000 blood products. A complication rate of 1:700 blood products was calculated. It is estimated that 53% of all incidents were reported.

CONCLUSION

Despite all of the safety measures taken, severe adverse events still occurred. A well-run system for haemovigilance can contribute to the knowledge of transfusion incidents. The safety and quality of blood transfusions can be improved if this knowledge is incorporated into ongoing education about blood transfusions and in the prevention and treatment of transfusion reactions.

摘要

目的

梳理荷兰西南部地区(约350万居民)的输血事件,该地区于2001年1月引入了输血事件区域报告系统。

设计

前瞻性、描述性研究。

方法

在2001年1月1日至2001年12月31日期间,22家医院自愿向血库报告患者的输血事件。所有事件均以标准化报告进行匿名记录,并分为14类。

结果

共报告了119起输血事件,分类如下:输注错误血液成分(n = 8)、轻度发热1 - 2摄氏度(n = 14)、非溶血性发热>2摄氏度(n = 36)、急性溶血性输血反应(n = 3)、迟发性溶血性输血反应(n = 18)、过敏反应(n = 11)、细菌污染(n = 3)、输血相关急性肺损伤(n = 1)、险些发生的事故(n = 6)和产品召回(n = 19)。在过敏性休克、输血后紫癜、输血获得性病毒感染和输血相关移植物抗宿主病类别中无报告。在开展血液警戒的同一年,血库共发放了158,000单位血液制品。计算得出并发症发生率为1:700单位血液制品。据估计,所有事件中有53%得到了报告。

结论

尽管采取了所有安全措施,严重不良事件仍有发生。运行良好的血液警戒系统有助于了解输血事件。如果将这些知识纳入正在进行的输血教育以及输血反应的预防和治疗中,输血的安全性和质量可得到提高。

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